sickle-cell disease
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a genetic blood disorder where red blood cells assume an abnormal, crescent shape, leading to various complications
Sickle-cell disease is a genetic blood disorder that affects the shape and function of red blood cells. Normally, red blood cells are round and flexible, allowing them to move easily through blood vessels. In sickle-cell disease, the red blood cells become stiff and curved like a crescent or sickle. These misshapen cells can block blood flow, leading to pain, infections, and organ damage. Symptoms of sickle-cell disease include episodes of severe pain, fatigue, swelling in the hands and feet, frequent infections, and delayed growth in children. Treatment for sickle-cell disease focuses on managing symptoms and preventing complications and may include medications, blood transfusions, and in some cases, a bone marrow transplant.
- Sickle cell disease results from a mutation in the HBB gene.
- Symptoms of sickle cell disease include pain episodes, anemia, and etc.
- Supportive care is essential for individuals with sickle cell disease.
- Public health efforts focus on improving access to comprehensive care for individuals with sickle cell disease.
- Sickle cell disease is more prevalent in individuals of African, Mediterranean, and Middle Eastern descent.